a 2100 carb does do well on the small six, and you have two options there, the best is a direct mount, but that means pulling the head and having machine work done. the other option is a 2v to 1v adapter, the only drawback to that is you lose hood clearance. vintageinlines.com carriers the adapters you need to make that conversion.
i used a 2100 autolite on my old 66 falcon with the 170, and it worked nicely with the 2v to 1v adapter. there was a bit of an issue in getting the idle to run cleanly though, but with a little effort it can be done.
Looks like I gave this patient the treatment she needed.
Hard starting
Wouldn't stay running stalled and wouldn't restart after a few minutes
1. Automatic choke housing was loose and not set properly
2. Timing off
3. Idle and fast idle off
4. Idle mixture off
5. Rubber fuel line section severely cracked
6. Metal fuel line too close to motor
7. Top carburetor screws loose
8. Lower carb base plate screws loose
9. Made sure 160 thermostat present and functional
10. Hot air vacuum line attached to fuel line whole distance
11. Installed Phenolic 3/16 spacer to base of carb to dissipate heat
12. Installed 5/8 thermoflex fuel line (good up to 750 degrees) covering entire length of fuel line
Ran for 25' yesterday in 87/99heat index weather with motor at 75% of temp guage towards "H" prior to this at 50% of operating temp would progressively studder quickly and stall then wouldn't restart for 90'. After that would start run perfectly then repeat presenting with Vapor Lock symptoms.
The 200 6 cylinder with The Autolite 1100 is notorious for vapor lock due to location directly above horizontal manifold.
Purring like a kitten now