you are reading to much into the casting #. The E6SE number is really only the very 1st part of the whole number for a part. It can be for a block, head, intake, etc.
E= Decade so this would be '80s
5 ,6 or 7 = year or 5th, 6th/7th year of the decade
A, S or T = Model A being Generic full size ford, S being thunderbird and T for truck
E= Engineered component so the "E" would be engine group
example would be "C" would be body & electrical, "H" would be climate control.
The Engineered component number is the 4th digit in the part number and always an alpha letter. It identifies which Ford engineering group designed the part and to which major component group the part belongs to. It does not indicate a revision or engineering change.
Ford would design a part for specific body line like the thunderbird, trucks, etc but most parts are not limited to that line. The block changes over the years are well documented, I'm very comfortable stating that the block is the same.