I believe it..
1st off... contrary to popular belief, nitrous is no harder on the engine than any other modification that would increase horsepower. Of course, this is only if you ensure a proper tune.
So.. letse. A stock 289 makes what? 200FWHP? I think a stock 289 would be able to handle 375FWHP (approx 325RWHP) with little problems.
Also remember... we're using this stuff in 10 seconds spurts here.
I'm running the stock bottom end in my 351W (cast pistons and all). The engine was a recent stock rebuilt when I got it.. and when I bought my nitrous kit, I couldn't bring myself to rebuild a perfectly fine bottom end. I decided I'd hook up the N20 (Jetted at +150HP) and run it till it broke. That was 4 years and many bottles of N2O ago. The ole 351W is still running great and shows no sign of wear since the day I bought it.