What are your goals for the car? All out performance? Cruiser with an occasional trip to the strip? Will never see a drag strip? Road racing?
Your 300 6 sounds built to the 9s. I frankly wouldn't have thought it possible to get the power you describe, unless I'm misunderstanding your post. Maybe you're running 13:1 compression and E85; I don't know.
Anyhoo, knowing your goals will help people to recommend gears. I had a 250 6 in my convertible at one time and I think that engine liked tall gears (like 2.80 or so), because it wouldn't wind out. It had a lot of low grunt but nothing up top. If your 6 really makes over 300 hp it must be winding up to a higher rpm than the sixes Ford built in the 60s!
It would probably be good to post your power band too. For instance, if it's a drag car you might want to go through the traps at the top of your power band in fourth gear. We would want to know what rpm and what size tire to calculate the number.
Too much info?