i think that could be more difficult than you think. probably more expensive than buying a used kenne bell for the 5.0.
you'd have to worry about the lower mounting to the 5.0 and making sure the snout matches with the serpentine belt. not saying it can't be done, but just not cost effective.
As with anything mechanical.. yes, without doubt it can be done. Is it / will it be cost effective.. no way. custom brackets, blower drive and lower manifold of some kind, and remember the 4.6 doesn't have pushrods and such to work around..
Kenne Bell is the best answer for a whipple style blower for our cars.
I am thinking it is very possible but yeah cost is probably getting close to a Kenne Bell PLUS I am thinking that hood clearance may be an issue as well...