Consider that if the front O2 sensor were turned off, this would make the PCM run in constant "open loop" mode. Your mileage would be terrible and likely the driveability would suffer a lot. IMO, it's far more likely that the REAR O2 sensors have been disabled because the cats have been removed.
Recommendation, ignore the rear O2 sensors. Bank 12 and 22. Pay attention to ONLY the front O2 sensors (bank 11 and 21). OBTW, bank 1 is the right side. Bank 2 is the driver's side.
So the front right is 11. The front left is 21.
OBTW, WHICH cylinders are you getting a misfire on? For a coil pack application, sometimes it's possible to gleam additional information if a "paired" set of cylinders are misfiring. Why? Because it points to a possible common cause.
For a V8 coil pack application, the paired cylinders are:
Coil #1-cylinders 1,6
Coil #2-cylinders 5,3
Coil #3-cylinder 4,7
Coil #4-cylinder 8,2
If considering cleaning the fuel injectors, consider an injector cleaning/flow test service such as InjectorRX.com. Once cleaned and tested, the injectors are as good as new. Cheaper than new.
FWIIW, A circuit malfunction DTC is usually wiring, coil pack, or PCM (bad coil driver) related. Since the coil pack are new, this should be ruled out. So that leaves the connector, wiring and PCM.