Zookeeper is right. I've had three 67-72 pick-ups over the years, plus various other chevies, and did an engine swap (among other things) in my buddies Z-28. Engines, intakes, trannies, you name it will swap. My biggest problem was keeping starters from cooking behind the headers on my last truck, but I was having a hard time finding ram horn manifolds. Now that I don't have the truck a pair surfaced in another friends garage.
Oh, and parts are cheap like borscht. The real draw back to the chevs though is esthetics and fit & finish. I don't think they ever built a decent door mechanism. You can put up with a windshield washer that doesn't work, but a door that you use multiple times a day should work well and at the least be easily serviceable.