New user 2010 V6

Greetings. I knew to the forum (obviously). lol. But I’m desperate. I have a 2010 V6 base model that’s a ton of fun to drive and right now is also my daily driver. I have a confirmed cylinder 2 misfire. It seems heat and load specific. What I’ve done to date.
Changed all plugs, wires, coil pack and injectors. Both north and south O2 sensors as well on both banks. Still a number 2 misfire when hot and even more under load. However even that is not consistent. This problem came out of nowhere about 4 weeks ago. I s owned this car since 2010. (New). Has 119k miles. Looking for suggestions, ideas. Or. Know. Issues. Thanks.
 
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Try going through [all] of the hoses and plastic lines in, on, and around that engine. Look for cracks, holes, and chaffing.

Have you pulled OBD codes? Is a code reader your misfire confirmation? What other codes did/do you have?