You can but it makes the tune all the more important. A guy in 5.0 mag had a simple setup with the stock bottom end and a powerdyne and he spayed a 40 shot, he said the nitrous was more like an intercooler than a power adder. Its in the may '04 5.0 pg.78....his paint job looks sweet
I don't know that much about the two but from what I have learned and read. I know that boost heats up the air, and nitrous cools it down, so you probally could run more boost with spray taking your block can handle it.