That's so true.
Start with the basic's- Adjust the float's, ensure that both primary and secondary's are fully open at WOT, set the idle speed and mixture, etc.
From Holley, your carb came with a few different Jet combo's depending on the generation you have.
They are: List # 4776- F: 69 R: 71
4776-1 and 2 F: 66 R: 76
4776-3 and 4 F: 66 R: 73
All versions came with a 6.5"hg Power valve.
Post you're combo and we can give you a better idea, but in most applications, the 6.5 PV is just about right for the street.
You need to go for a short drive and use only light acceleration, and just cruise at a steady 30-35 MPH, don't get on it at all. Shut the ignition off at speed and coast onto your street or into your driveway, then pull the plugs and read them. You want a nice light tan colour on the electrode, grey or white indicates you are too lean, and dark brown or black indicates too rich. Jet the primary's up or down in 2 size increments if needed, then re-test. Keep doing this until you get that light tan colour on the plugs.
Example: If it's lean, you would go up from the stock 66's to '68's and then retest. If it's rich, you would go down from the 66's to 64's.
As for the secondary's, the procedure is almost the same, except you floor it to WOT, then shutdown and read the plugs. Jet up or down if neccesary and retest.
Once you have it jetted, then you can work on the accelerator pumps. If you have a flat spot or hesitation during light acceleration, you need more of a pump shot. To adjust the pump shot on the primary's- Just move the leaver to the next hole on the pump cam and retry. If you run out of adjustment, you need to try a different colour pump cam.
If you get a bog- It falls flat on it's face, then picks up, you need a smaller pump shot. Again, if you run out of adjustment, you will need a different pump cam.
On the seconddary's, the same thing apply's, except this time you are looking for the hesitation or bog when you mash the throttle to WOT. Curing the issue ids the same.
Definately pick up a book on Holley Carbs- Your local parts store should have one, or at least be able to get it. They are invaluable.