Would it run Without EGR spacer

I would think so, you may have to pull the egr sensor and tuck it away while its plugged in, just to trick the computer. This may or may not throw a check engine light. But i wouldnt see why it wouldnt run!!!
 
I removed mine and replaced it with a 1/8 inch piece of plate steel cut to match the TB diameter and with a mounting flange for the throttle cable.

Easy. Took all of an hour to complete.

I don't have cruise, so not sure how that might affect things.

Good luck...