It all depends on your goals. If you are looking for 800+ horsepower, and want to do anything other than dynoing it, forget the compound boost. I LOVE compound boost as much as anybody, but at over 800 hp, it simply isn't reliable. There is just too much heat/boost there to safely tune. Even on a great, safe tune (which is pretty hard to do at 800+ hp), one bad batch of gas, and bang. Don't believe me? Search around and see how many big horsepower compound boost Cobras are still around....
Now if you're looking for 750ish rwhp, compound boost is a great option. It's still capable of being tuned to allow some margin of error, and will produce ridiculous amounts of torque low in the rpm band. Personally, I'd port the blower to the max, and pulley it to around 8-10 pounds of boost. Then, throw in a single 67mm billet wheel turbo (or twin 57s if you have the money and want it to spool REALLY quick) at another 10 pounds or so. Can't say for sure on a 2-valve, but that's an easy, relatively safe 700-750 rwhp with a HUGE powerband on a 4-valve.
Yes, as confirmed, you cannot do compound boost with twin screws. The manufactures themselves say not to do it. Only with roots style.
On this whole "boost" thing. Boost is only a measure of restriction. It doesn't (necessarily) mean more horsepower. For example, a fully ported, fully pullied Eaton on a 4-valve Cobra is going to make around 15 psi of boost. Now, go stick that exact blower on NPI 2-valve heads. I'll bet the boost will go to 22+ psi, but want to bet which makes more power? That should be common sense. Bottom line being don't let someone sell something to you based on boost numbers.
The TVS is also a good option. At the power you're looking for, go with the 2300 for sure. They are GREAT blowers that are as efficient (or even slightly more) as twin screw blowers at less than 15 or so psi. Personally, I wouldn't bother spending $1500 on a M112 port job; I'd put that money towards a TVS instead. Heck, a fully ported, pullied 2300 would probably put you close to the goals you are looking for. On an auto car that'll hook, that combo is an EASY 9 second car.