It would help but I would not say its an absolute MUST. You would gain more from the timing curve change and A/F change...probably not much from any tune related to the cam/inj timing aspect.
I ran mine basically stock without a tune. Bone stock gt40 heads, ported gt lower and TFS cam. I ran on the gt pcm but it ran fine...except for the C&L I had for the 24#inj...but that was not a fault of the cam. Ran 13.5 @ 102 with a 2.3 or 2.4 60ft the first and only time that combo went to the track...my average was 2.0-2.1 on street tires prior.
I would say use the money for upgraded springs for the TFS1 cam. I know my gt40 heads springs were not up to the task and they were off a 95 cobra...cost about $200 installed for beehive's IIRC 7ys ago.