You're not going to win a race in 1st gear. You win it in 3rd or 4th, depending on how fast you want to go.
I'm planning on adding a Vortech with my 4.10's. It NEEDS it. 1st is quick, there is NO doubt about it, but 2nd through 5th needs some grunt.
A good friend of mine had a 411rwhp Vorteched 02GT with 4.10s and it was a BLAST. I recently drove his car again when he swapped out for 3.55's, and it's a DOG down low, and it seems to take forever to get into boost....for daily driving. He swapped because he was hitting the rev limiter in 4th crossing the 1/4 mile. But he still claims to this day that 4.10's and a blower are awesome on the street. I heartedly agree. I've driven both, and I wouldn't have it any other way.
Now, if you were going with a KB, I would look at going with 3.73's, just because gears ARE a torque multiplier, and it might have traction issues down low.
But in any other situation, 4.10's all the way.
Hell, instead of spending all the money I did on my 15 exhaust combos, I could have bought a t56 for my 4.10's.