Does anyone else have a combo close to this

The duration and overlap maybe be an issue for clearance on stock pistons, would have to check it. you can cut the relief in stock pistons If need be. Had similar combo years ago with first gen afr 165's, more lift but way less duration on a stock shortblock with no clearance issues, made over 400 only time it was dynoed on an engine dyno.. Most grinds for that combo with the stock releif 302 pistons you will notice are kept around or under 225 at .050 numbers. Best to talk with who evers doing the cam for it. Lift has little to do with clearance, its the timing of the lift in relation to where the piston is.

Great advice above. Kind of an assumption but do you know how to clay the pistons and check for clearance?

Don't the 165s have 1.90 valves? If so stock pistons should have plenty of clearance with 227/540. Yea you should check, but I know I'm right. UNLESS IM wrong about the 1.90s.