Diagnostic Trouble Code (DTC) 543 indicates a fuel pump secondary circuit failure between the B(+) supply and the Fuel Pump Monitor (FPM) connection to the power-to-pump circuit. 99 times out of 100, this DTC results in a no-start condition.
If the engine starts and runs, the it is a pretty good indication there is a problem with the Powertrain Control Module (PCM). NOTE: Due to the internal circuitry of the Powertrain Control Module (PCM), a left/front Heated Oxygen Sensor (HO2S) signal short to power could produce a Diagnostic Trouble Code (DTC) 542 or 543