How long can a stock block/bottom end hold up

well im lookin for a project and i was wondering how long will a stock block/bottom end hold up. banking on i find a car with a pretty strong motor, i would like to put lets say the trickflow h/c/i setup and maybe a little A-trim s/c. any idea on how it would take it? i would eventually build another motor(347 or 392 or somethin w/turbo), but that will take time/money. would the lil supercharger hurt it a lot, or would i be better off w/o it. if this makes no sense let me know.