For the majority of bolt-ons, stock 19# plugs are fine. I was up to 270 RWHP w/ my 19's and the car did not lean out on the dyno during three WOT pulls.
That being said, with a good tune you can swap injectors anytime you feel like you're pushing your luck. I swapped to 30's anticipating cams and P & P heads with no driveability issues.
There is nothing to be gained from injectors except the ability to meet the fuel demands of more horsepower.
When you're making enough power to require an injector upgrade, it's a good idea to start looking at the fuel supply to the injectors. In a typical returnless system, the stock rails are adequate. The fuel pump is another matter. The most common upgrades seem to be the Aviator pump, the Focus pump or the '03 Cobra dual pump/tank upgrade.
I'm not an expert, but I have experimented with my own set-up quite a bit.
Jay