POR15 is cool stuff, but it's also a PIA to use.
Yes you can spray it with a standard primer gun (never done it myself), but you will need (at a minimum) a real respirator or even better, a supplied-air respirator. No point having a car that lasts forever if you keel over. Note: you can only thin it with POR15 solvent.
All the instructions you could ever want are on the POR15 website:
POR-15 Inc.. Read them several times before buying anything.
DO NOT BUY A WHOLE GALLON!!!!
Yes, I know it's cheaper per ounce that way, but you'll end up throwing most of it away after:
1. It becomes contaminated. (Regardless of size, after it's opened, and if you're ultra careful, you might get a can to last a month before it gels)
2. You can't get the lid off (no kidding - once you get the stuff in the seam between the lid and the can, you will tear the metal paint-can before breaking the POR15 bond)
I buy the tiny 6 packs, stir the POR15 with a clean wood popsicle stick, use a turkey baster to remove a small amount to a disposable plastic container, clean lid and can lip with POR15 solvent, then close can.
If you're repainting an entire vehicle, then select a brand of paint and follow their instructions, using the manufacturers primer - thinners - prep recommendations. Do not mix manufacturers. In other words, don't use POR15 under your PPG paint job. Kevin Tetz has a great set of videos that are well worth the price:
Kevin Tetz's Paintucation - Paint Your Own Car!.