The hood would be fine, you'd just have this big hole in it because you'd have to remove the shaker. If you're talking about a roots on a Mach 1, of course someone would have to build one first.
It's already been done! Classic Design Concepts (CDC) took an '03 Mach 1 and pulled out the stock engine and replaced it with an '03 Cobra motor, complete with blower AND shaker!
I believe he is asking about the big roots style blower you typically see in chrome sticking out the hood...not the centrifigal(sp?) which is underhood.
It's already been done! Classic Design Concepts (CDC) took an '03 Mach 1 and pulled out the stock engine and replaced it with an '03 Cobra motor, complete with blower AND shaker!