Stroker Motor Timing Question

I got a 331 Stroker motor in my car with TrickFlow twisted wedge Heads and Intake, E303 cam, 75mm TB, MSD 6AL, Autolite 3492 gapped at 0.052-0.054 (ford spec), ect ect .. I got some timing questions ..

1) Do we need to have the car OFF when pulling the SPOUT out before adding/removing timing.
2) My car has a lot of hesitation if I am around 10* thru 24*ish pretty un-drivable with SPOUT out but at 30-32* she run's very good!
3) If I set it at 32* because I have aluminum trick flow heads when I pop the SPOUT back in should it drop back down to 10* as with SPOUT out is that setting the total desired base timing?
4) Any of you guys just running motors/setups like this with the SPOUT out successfully. (Locked out Timing I think you call it)

My car really need's a tune which I am working on now going with an Anderson PMS or QuarterHorse which I am sure I could do all of this right then and there in the tune.

Just really curious as I thought I was supposed to with SPOUT out set the base timing to 10* but seriously runs like crap yet setting it at 32* runs like a champ.

Any input would be greatly appreciated guys thanks ..

Also note this is at about 1400-1600 RPM I am at 32* not a 700 RPM idle.

Well the odd thing is .. if I unplug the IAC (Idle air control) the idle drop's back down just fine so I know the computer for some reason is adding fuel/spark I would imagine.
Also I thought the TPS voltage thing was a myth and the computer read's the voltage at KOEO and uses that as a base so monkeying with that was useless or am I wrong?
I will triple check for vacuum leaks .. but I am going to try your first option and see if I can get the timing back down .. I may have been running "LOCKED OUT" timing with the SPOUT out after the car had already been running for a few minutes before I pulled the SPOUT and set the timing myself. Also I wonder if my dampener has spun which I guess is a possibility. I will look into that too.. Thanks for the input.

Thanks for the help the computer's internal ground was shot inside of it which caused all these headache's. Found after testing the VREF voltages to the TPS, EGR and all the other sensors on the GREY/RED wire (PIN 46) from the computer.