turbo set-up qestions

i am thinking of going with a single turbo set up on my car. the question i get mixed opinions about is the actual routing of pipes. see the question i have is if i only do a single turbo, can i use just one side of the engine, or do i need to run both sides through the turbo. i have heard it will be fine, just spool up a little slower, then i hear the uneven pressure from side to side would be hazardous for engine longevity. can anyone help me out with this. basically what i am asking is if i can run a set up similar to a twin turbo set up, one header per turbo, only not run the other turbo. one side be like factory and the other side be ran through a turbo.

redsnake...thats exactly what i was trying to find out. i was unsure of it and had heard mixed opinions on it. from a fabrication standpoint it would be easier to do, and i wanted to know if it was safe or not, before doing that. u answered my question perfectly.