I always suggest staring EVERY possible electrical trouble shooting session with a through review of the charging system. A bad alternator diode will cause excessive AC ripple which can cause false CAM DTC's. Today's cars simply will not run right without a strong battery and alternator.
Howto perform charging system voltage drop test
https://www.stangnet.com/mustang-fo...perform-charging-system-voltage-drop-test.56/
Did the new misfires start after you replaced the spark plugs and COP's?
When the COP's were replaced was there any moisture or other debris in the spark plug well or on the boots?
Did you save the old COP's? If so, consider getting new COP insulator boots. Refurbish a couple and use the old COP with new boot insulators to swap through the misfiring cylinders.
Double check the spark plug gap. Misfires under load can be a sign of:
- Excessive spark plug gap
- Something bleeding off the spark energy (arching) such as moisture or high resistance connection.
- Combustion problem such as a lean fuel charge (clogged injector).
If you are willing to replace the fuel injectors as a trouble shooting step then consider sending the whole set out to InjectorRX.com. Once cleaned and flow tested they are as good as new. Cheaper than new. I have had great luck with their service and use them for every motor project I have done.
Consider renting a compression tester from your local auto parts store and perform a compression test so that the over all health of the motor is known.
I don't think this is a fuel pressure problem. Fuel pressure low enough to CAUSE a misfire would show up across all cylinders. Same for the fuel pump.
How many miles on this motor? If over 150,000 consider the possibility of worn timing chains or broken chain guides. Do the chains make noise on start up? If yes at the minimum the chains have been stretched.
Consider getting yourself an oil filter cutter. Cut the oil filter open and inspect for debris. I do this on EVERY filter change of all the cars/trucks my family own. So far it has saved two motors. Here's the one I own but there are others slightly cheaper.
https://www.summitracing.com/parts/lng-77750/overview/
Finally consider getting yourself an ODB2 scanner. The ability to monitor operational PID's can be a trouble shooting game changer. Here's some information on an affordable Windows based unit.
ForScan ODB2 scanner w ELM327 USB
https://www.stangnet.com/mustang-forums/resources/forscan-odb2-scanner-w-elm327-usb.57/
One of the biggest advantages that having an ODB2 scanner will give is the ability to test more and perhaps replace fewer parts without a "fix".