Gear swap is possible, you just have to remove the halfshafts and lower the diff out of the IRS subframe, then its a pretty much straight forward gear install.
10.5's might be pusing it, there ARE clearance issues as the IRS subframe takes up a substantial ammount of space. Sometimes people run into problems rubbing against the bolts which mount the rear of the subframe to the chassis, they either grind them down or buy low-profile bolts... Still 10.5" is a big wheel, and depending on the backspacing/offset may not work at all (without spacers).