The previous posters all make good points. This also dovetails into the advice about your goals.
Everything that follows is IMO.
I would never take the car to the track. It would be 100% street. Therefore, street drivability is a prime concern. In my mind I would easily pick torque over horse power because a high HP engine that doesn’t make big HP unless highly revved doesn’t make the best street combo. Low end grunt for me.
Further, I am not made of $$. I could never afford an all out build.
Next, I would want to do as much of the work as possible myself. Therefore, I would pick a reliable power adder
kit where the engineering work has already been done.
For me, that would be the Kenne Bell supercharger. The KB kits are well engineered. A proven design. Make tons of low end torque.
With regards to your choice of block. Great idea!
However, I would not de-stroke it. I might consider an over bore but that is all. Again, back to my goals. A reliable street engine. Excessive over boring and stroking tend to reduce reliability.
Regarding your choice of heads. Since my goal is a street motor running on pump gas, the lower compression ratio is better (boosted application). Also consider that in a boosted application, the advantage of high flowing heads is somewhat reduced verses stock heads (boosted verses NA). Again, if $$ is no object, go for the best. If trying to stay with a budget, stock heads may fit the bill.
Again, the choice of heads also depends upon your HP/torque goals. If your goal is to make 500 street HP, Stock heads will work. If your goal is 1000 HP, then every imaginable method to increase flow will have to be considered.
Consider reading Sean Hyland’s book “How To Build Max-Performance 4.6-Liter Ford Engines”.
Amazon.com: How To Build Max-Performance 4.6-Liter Ford Engines (Cartech) (9781932494686): Sean Hyland: Books
For me, I believe in the KISS theory. In that regard, I would tend to use a combination that met my goals but was already proven. I would not want my project (and $$'s) to be on the “bleeding edge”.
If you want real world examples of what happens when parts are assembled without a plan, just look at the "for sale" ads in the forums. Lots of nice parts without a home. Projects started with unrealistic goals and/or not enough $$.
I hope you can see how the choices should fit the design goals. In the end, this is your project (and your time and money). Good luck.