general rule of thumb is 1.5 to 3 turns out depending on how the thing idles.
Set your timing, then your idle speed (650ish with a stockish cam)
Then turn the screws in, CW, about a half a turn per side, go back and forth side to side.
If the idle mixture screw setting is the problem, the idle will clean up, and should speed up and run more smoothly.
likely there is something else wrong with the carburetor, like a previous back fire blew out the power valve diaphram, so you're getting fuel through that circuit when you're not suppose to be.
If it's still in print, pick up the holley carburetors and manifolds book from HP Books, GREAT resource.