I know guys with 289s that run 12s without NOS. One coupe that ran 12.8s had 3000stall, 4.11 gears, Alum. heads with 2.02 intakes, and a .500" cam. 3000 stall is a huge help to a reving engine, especially when the bottom end lacks torque. Even a 2200 stall would help a lot. Getting the right shift kit for a green dot tranny is tricky, so you may want to leave the inside of the trany alone. It took a while before I realized that to control the 2-3 shift, I had to move the shifter back to 'L'

. Also, gears make a big difference. I run 3.40s and get decent milage on my 300 mile trips to Cal Poly where i go to college. I run at 3400rpm all the way down the freeway at 75mph. Get a well built exhaust system.
Heres what I recommend:
AFR 195cc
2800 stall, though you may want to go higher or lower
a strong cam matched to the stall amount and your compresion
Speed Demon 650cfm
3.50 posi
Performer RPM intake, i think the air gap version might be too tight
NO POINTS IN THE DISTRIBUTOR!
2.5 exhaust with H-pipe, 2 chamber flowmasters
As far as tires go, I cant say what to run, but
air down! Not too much though: the sparking traction from aluminum rims, when the tire comes off, is not a fun experiance.
Don't forget that everything inside your car has to be accelerated to 100mph at the end of the track. The less it weighs, the quicker it will be.
also, props to the 14.6sec 302