New user 2010 V6

Greetings. I knew to the forum (obviously). lol. But I’m desperate. I have a 2010 V6 base model that’s a ton of fun to drive and right now is also my daily driver. I have a confirmed cylinder 2 misfire. It seems heat and load specific. What I’ve done to date.
Changed all plugs, wires, coil pack and injectors. Both north and south O2 sensors as well on both banks. Still a number 2 misfire when hot and even more under load. However even that is not consistent. This problem came out of nowhere about 4 weeks ago. I s owned this car since 2010. (New). Has 119k miles. Looking for suggestions, ideas. Or. Know. Issues. Thanks.

Noobz347 said:

Try going through [all] of the hoses and plastic lines in, on, and around that engine. Look for cracks, holes, and chaffing.

Have you pulled OBD codes? Is a code reader your misfire confirmation? What other codes did/do you have?

Click to expand...

I did a drive monitor test and it’s showing lean and fat mixtures on cylinder 2. I finally bought a cover and parked it. I think later this fall or over the winter I’m going to tear down the top end and just replace everything. I refuse to scrap the car even though some people (not here) call it the “bastard car” because it’s a 2010 with the 4.0.
I was in heavy traffic on a hot day the first time it misfired. So I do t know.