While 3.73 may work best for you in a LIGHTNING, the majority of COBRA owners opt for a higher gear ratio instead. For reference, here's why (as taken from Alternative Auto's site):
4.6L Mustang Tech Q & A
Damn, just when I thought I had my mind made up on the 4.10's
Well now Im thinking 4.30's again... I guess even if I ended up going into 5th at the track, that would take some boost to get there and with the T56 having a 0.8x 5th gear ratio (if I remember correctly) then it wouldn't be that much of an issue 