I personally have a Tweecer, and I am having a lot of fun with it.
Pros: You can tune as you go. It gives a whole new meaning to the term "test and tune" at the track. Make a pass, notice you are detonating at higher RPMs? Take out some timing in the higher RPM range. Notice you are running a little lean at a specific point? You can adjust your trims in between runs. You have 5 switch settings, that can literally be changed "on the fly". One is for your stock PCM calibration, and the other 4 are for your own custom tunes. You can have a daily driver tune, and aggressive track tune, an aggressive track tune with backed off timing for nitrous, and a bad tune you can use as a theft device. Or do what ever you want in those settings. If you change something on your setup, like go with a different MAFS, you don't need to spend the money getting a chip recalibrated. You simply make the changes yourself. You can even diagnose problems by monitoring different sensors. Even before you start tuning for performance, you can dial in your injectors and MAFS, which will most likely clear up most of your driveability issues.
Cons: Very steep learning curve. I am reading everything I can, I must have 20+ pages and sites bookmarked for me to read through. I have not even begun to scratch the surface on what it can do. There are a few sites dedicated to tuning, but to be honest I haven't found any of them to be helpful. There are a couple members here who have helped tremendously, and I am grateful for everything they have helped me with. But other than those few guys, I would say you will find yourself on your own for the most part. It is very much a "learn as you go" type of thing. I am finding that most of the info out there is designed for those who already know what they are doing. I read a lot of things that say "you need to change this or that"...but there is nothing telling you HOW to change those things. I spend a lot of time reading and playing, and like I said, I have only begun to scratch the surface.
All in all, I love the Tweecer. It is a LOT of fun, if you want to learn something new. The advantages are endless. If you go with the Tweecer, also go with a WB o2 sensor, and opt for the Tweecer RT. Not being able to datalog will make tuning much more difficult.
Be sure to ask around, there are a few guys on here who are pretty knowledgable using the Tweecer.