R12 was the orginal refrigerant, but R12 is now longer being manufactured. If you can find a shop to recharge with R12, it costs $45-$65 a pound, the system takes about 2 pounds.
If the system has been converted to R134a, the service intake fittting on top of the compressor should have a blue cap and a quick disconnect type of fitting instead of the screw on service intake fitting.
Just look at the contents, alot of the substitutes are propane or other flammables. You don't want flammables in the front of your car if you crash it.
See http://www.aircondition.com/ for help on alternate refrigerants. Some do not come in the 1 lb cans, and require specail handling when recharging the system.