I agree with Nate on pretty much everything except the cams in stock NPI heads.
IF 260-280 rwhp is all you are looking for (and don't get me wrong, 260-280 is a LOT of fun for a DD), then yes, NPI specific cams in the stock NPI heads (along with a PI intake) is a good choice. But do be aware that those heads are going to be a huge restriction at the point. You WILL NOT make any more power NA than that. If you add boost down the road, you will be looking at 350-360 rwhp at the most, and that's it. There is no more than that unless you
really push a lot of boost/nitrous through it, and that's a bad idea. If that's good with you, then go for it.
Knowing what I know now, I would have gone PI a LONG time ago. For people that don't know, I'll sum up my experience right quick.
1. Stock PI cams and PI intake on stock NPI heads. Most of the bolt-ons. Had a fun low 14-second street car. Would be several tenths quicker with gears or 5-speed.
2. Slapped an SVO blower on it at 7 pounds of boost with no other changes. Made 310ish rwhp, ran mid-high 12s consistently. Was a DAMN fun car on the street.
3. Threw a set of MHS blower cams in it (NPI head specific), as well as a slightly smaller pulley and methanol kit. Made 344 rwhp (uncorrected on a warm day), and lost a piston due to detonation less than a week later at the track. From the looks of it, it would have run 12.2-12.3 pretty easily in that trim.
4. Got a low mileage PI motor for cheap. Swapped the blower onto it, as well as the MHS NPI cams. I haven't gotten it on the dyno yet (or track), but I can say with 100% certainty that it is making way, WAY more power. I'd guess 40+ more rwhp. I'll know within a couple of weeks for sure. I'm almost positive it will go 11s with relative ease in good weather.
So, all this being known, I would have gone PI awhile ago. If I thought I wanted a blower at some time, I would just do an entire PI motor so that it doesn't raise the compression. Or if I just wanted an NA car, I would have done the PI headswap with a mild set of NA cams.
^That is just my personal opinion on the matter, and is what I would do if I had to do it all over again.
And for what it's worth, it is hardly any extra work to remove/change the heads once you have the cams out. It is literally just a matter of unbolting the exhaust manifolds from the midpipe, and removing the head bolts. THAT easy.
A PI headswap with stock PI cams and bolt-ons will make 260ish rwhp, and run low-mid 13s with a competent driver. Many people don't have a good understanding of how fast that is, but it is MORE than enough for a very fun DD. Add a set of cams while you are at it, and you're looking at 300-310 rwhp and a car that should run mid-high 12s with a good driver.
Oh, and I have NO driveability issues with my Stage II blower cams. It idles fine, plenty of torque down low, etc. I freaking LOVE rolling up to a stoplight, slipping it in neutral, and listening to it rumble.