Most tuners just set the tables to run off of a single table. I believe I just added 4* to all tables across the board, because I run aluminum heads, and then pulled back a bit where it was already asking for 40* at cruise. I basically add what I think is right and listen for knock. I might have added 6* on the WOT table.
Here's the thing, you can't know what optimal timing is on your setup without a dyno and tons of tuning time, or pulling plugs a lot after getting the fuel right. You can do WOT timing at a track vs acceleration, especially if you have speed in the datalog (RPM with gearing). That really takes some programming and math, though. Or, you can simplify and just adjust the curve globally watching trap speeds until it doesn't gain anything.
Realistically, either pay a tuner, or just post your setup, here, and we can chat about some universal adjustment.
All of that said, you should be focused getting fuel right, and only after you're happy with your fuel settings should you worry about timing.