Same deal, just to a greater degree.
Well, I see it like this. If you're running a set up that requires more gear to function properly with say an aggressive H/C/I combination, they you're certainly not the "cruising"type. You fall into the latter category of guys who like to drive with their foot in the oil pan and with that kind of top end, you probably aren't very concerned with fuel mileage anyway?
There's a wide margin of gear choices between 2.73 and 4.10 for a person to choose from, so it's safe to say one could find a decent compromise in there somewhere that would both wake the car up to some degree and retain some semblance of their highway manners if they wanted to.
FWIW, my mileage dropped about 3-4mpg going from 3.08's, to 3.73's. Yes, it made the car more responsive during jack-rabbit starts, but considering that kind of driving only encompasses less than 5% of my driving habits, the compromise in highway manners, passing power and fuel mileage wasn't worth the gain in acceleration.