If you're unbolting the quads, it really shouldn't matter if the suspension is loaded or not. They will extend when you get them off (unless they're shot) but they won't shoot out or anything. I've had mine off and on a couple times.
I replaced my LCA's and replaced the quads & shocks - they are there to prevent wheel hop, which was apparently a problem with the stock suspension. However, I've heard a lot of people say they're unnecessary with quality aftermarket components. Only way to know on your car is to try launches both ways - if you have a problem or notice a performance difference leave them on.
Just a couple thoughts.
Jay