If I remember right the Chrysler motor seals the chambers. The intake valves are a huge restriction to efficiency. Air being pulled past the valves creates a large amount of drag on the pistons. Also, the air that is compressed in the cylinder returns the energy lost, almost completely, when it expands.
Do not try to do this by unplugging an injector, and definitely don't pull a spark plug. The motor will barely run if at all. You will not get the desired result in increased efficiency. The computer will only see that there is only enough fuel going to each bank for 2 cyl (via the O2 sensor), and further enrich the 2 cyl that are running. I would assume that the computer would then see that duty cycles for the 2 running cyl were doubled (in reality they would hit 100%, since they probably run at 80-85% now), and completely freak out. Codes would be thrown, and even if mechanically the car could run, the electronics may prevent it.
Pulling the plug out will be just as bad. Even if the computer doesn't flip out, you will be loosing a great deal of efficiency by pumping air through the small spark plug hole, on both the compression and exhaust strokes.
The details of this system are a little fuzzy right now, I will have to read up on it again. I'll post when I find the article.
I like that you guys are thinking outside the box, but this won't work without some trick electronics, and a fair amount of mechanical planning.
Anyone know if the chrysler motor is still available? Last I heard it was not selling near as well as expected.