The drivetrain loss is about 20-22% with a C4.
I don't know about the C6, except that it soaks up quite a bit more power.
I have heard, don't know the accuracy, that if you change from C4 to C6, you will lose about 35 rwhp on the dyno. With no other changes of course.
Also have to look at weight...
100 lbs is equal to 10 rwhp or .10 sec in the quarter.
So once you start driving, you not only have the extra parasitic loss of the C6, but you have the equivalent of another 1 rwhp per 10 lbs of weight added by using the larger tranny.
250 fwhp with 20% parasitic loss, gives you 200 rwhp.
That said, I believe that Ford had a habit of underrating their engines in the late 60s-early 70s. Even the smaller V8s.
If they were going to get Uncle Sam and the insurance companies to believe the 428 SCJ only made 335 fwhp, then they couldn't rate the 351w 2v at 300 fwhp!
Dave