My son runs a Cartech box on GT 40 lower, and he was surprised at how little low end was lost (I wasn't, I am a firm believer in letting a short stroke engine spin up.), and how much throttle response was gained. That thing revs QUICK now, since it doesn't have to get a ton of air moving between the throttle blade and individual runners. (The reason SN95s have lesser throttle response.)
He has a stock cam and heads, with 4.10 gears, T5, and Explorer TB...