If I recall correctly, the Coyote used the exact same bolt patterns as the earlier 4.6L mod motors. Ford wanted to save cost by using a lot of the same production line tooling. In fact, from a fundamental standpoint, the Coyote 5.0 is basically just a bored and stroked 4.6, since it shares the same bore spacing and deck height.
In other words, I believe it is (at least mostly) bolt-in. As far as wiring and computer stuff goes, you'll probably need one of FRPP's control packs, or a computer/harness from a donor car.