Considering that combination, I figured I'd comment, regardless of the distinct possibility of BS.
1) Even with the fairly recent increase in aftermarket support, the FE motors are a lot more expensive than a 429/460 motor. Although I do have a soft spot for the old FEs, I still believe the 460 to be a superior design.
2) With an engine that's making 600+ ft/lbs of torque in a car that would weigh about 2900 pounds, the last thing you need is 6 gears. Hell, a modified automatic with P R N D would be sufficient. Screw 1st and 2nd gear. Why bother with gear reduction when you can smoke the tires in direct drive at 100 mph?
3) Independent Viper rears are cool. For a Viper. But with a big block in a II, even an alum. one, the nose weight alone(they're bad even with a 302!) will ruin its handling, regardless of IRS or no. Unless you plan on moving the motor and firewall way back under the windshield and mounting the seats where the rearseats used to be, you're not going to have anywhere close to 50/50 bias. Not only that, but the Dana IRS found in the Vipers would end up thrashed by a motor making 200+ hp more than the factory Viper V10. A 9" rear is a million times(at least) stronger than that Dana unit. Also, single plastic tranverse springs suck. Come to think of it, almost anything plastic sucks.
Build yourself a nice 610" 460 motor with some big heads, a single-speed automatic, 9" with 3.00:1 L, and you're good to go street cruising. Forget all that fancy IRS/6-speed stuff, dude.