absolutely, no doubt about, you would be able to tune it with the tweecer. you have control over pretty much every possible parameter in the computer.
the "problem" with it is that there are so many tables and functions that you have access to, it can be hard figuring out which ones to mess with and which ones to leave alone. grady and i use one and our drivability is excellent.
EVERY combination of MAF and injectors in the world is compatible with the TwEECer, because the way it works is that the MAF sensor provides a voltage to the computer, and the computer takes that voltage and looks in a table (the MAF Transfer table) to derive how much air is coming in. the computer then decides based on that info how long to open the injectors for. since you can make the MAF air flow and injector flow info correct, the computer can decide correctly how long the injectors should be open. so as you can imagine, the MAF transfer table and the injector flow parameters need to be as correct as possible.
another piece of the puzzle for tuning our cars is that they are load based. this means that the computer takes the amount of air it thinks is coming in (the same info as above) and what it thinks is the size of the engine (another parameter) and uses that to decide what percent of the engine's maximum air flow it is getting. it then uses that for many of the other decisions it makes (which you have control over) including the spark timing and injector on/off timing.
one last thing i'lll mention about the tuning is the long tubes problem. the stock computer thinks that the O2 sensors are a certain distance away from the cylinders, and it uses that to decide how long to wait before looking at the O2 voltage while trying to figure out if it gave the right amount of fuel. it then uses that info to add or remove fuel in the future in its attempt to make it better (this is called the adaptive strategy). when you get long tubes, that moves the O2 sensors farther away, so the O2 reading it takes is incorrect because the exhaust has not yet gotten to the sensors. then as you drive the car, the tune will get worse because the computer's adaptive strategy fails because it is reading the sensors too early (because the O2s are farther away then it thinks they are). that is a primary reason why the car drives better after disconnecting the battery and gets worse (again!) in a few days. the adaptive strategy is reset when you disconnect the battery.
and yes, you can fix that too with the tweecer.
that said, i bet many of the other tuning systems also provide access to those parameters, so the tweecer is not the only solution for you
good luck and keep us posted