I'm right at 14# and lifted heads at 21* spark, 11:7 commanded AFR. Never heard detonation, just ran slightly hotter than normal and overflow bottle was full, track times were slower.
Ran 12.3 with good head gasket, 12.6-12.49 with the bad ones, laid down a little up top when I got to high boost. Never heard detonation. Car has at least 30-40 WOT runs on it w/ the S-trim at 18*. About 10 runs with the higher spark before the gasket went.
This was on 137k mi virgin stock longblock.
If you are concerned about keeping it safe, I wouldn't go much over 12# and 11.5:1 @ 18deg total.
Wes