An injector is just an electronic valve. The computer just determines when it opens, and how long it stays open. Like any flow system, if you increase upstream pressure, flow rate going downstream increases (within limits of efficiency). So for the same pulsewidth (time the injector is open), a higher fuel rail pressure will move more fuel through the injector and into your intake port.
Something that is often misunderstood, is the fuel pressure regulator does not maintain a constant static pressure, but instead a constant pressure differential between the fuel rail and the intake port. In other words, if you have your fuel pressure set to 40 psi, it is 40 psi HIGHER than the pressure in the manifold. So, if your throttle is closed and the manifold is pulling a vacuum, the regulator LOWERS the rail pressure to maintain 40 psi over whatever the manifold pressure is. In this condition, it will appear to have less than 40 PSI on the gauge, by however much your manifold vacuum is. If you're at WOT and you are pulling zero vacuum, then you should have 40 psi gauge. That's why you set fuel pressure with the vacuum line disconnected, so the fuel pressure regulator "thinks" your manifold is at zero vacuum.
Fuel injectors need some minimum amount of pressure to produce an ideal spray pattern. Because of that, I would never lower fuel pressure under stock settings.
There are ONLY two ways to use a non-stock sized injector:
1. Retune the computer to recognize the change in injector flow (ideal way).
2. Use a "calibrated" MAF meter (less ideal). A "calibrated" meters returns a falsified voltage to the computer to indicate that less air (if using a larger injector) is coming into the engine, which will cause the computer to trim the amount of time the injector is open, thus reducing the fuel flow into the intake. At higher rates of airflow the larger injector is held open the same amount of time the stock injectors would have been, and the modified engine gets the fuel it needs. While good "calibrated" meters can perform well at WOT, the downside to them is that startup and low-rpm operation can sometimes be negatively affected.
Changing injector size without taking one of the above steps will never result in 100% ideal drivability.
Cirling back around to pulsewidth- just like a cylinder head intake port, if the engine is demanding more than the injector can supply in the time that the (injector) valve is open, you've hit a wall. The computer can (and does) increase the pulsewidth, but at some point the engine will close the intake valve and you've run out of time. Increasing fuel pressure can only get you so far here, and at some point you have to raise your game on injector size. This concept is known as "duty cycle". Duty cycle is the amount of time that the injector is open, relative to the time it takes for one engine power cycle at a given RPM, expressed in terms of percentage. A duty cycle of 100% means it is open constantly, and 50% means it's open half of the time. Generally speaking, it's not advisable to exceed 80-85% duty cycle.