PREACH!5spd GT said:4:10's will have worse gas mileage. Higher cruising rpm on the interstate.
If you do a lot of interstate or highway driving, I wouldn't do it personally on a actual daily driver.
The main reason in my opinion that many with these 4.6L's want the 4:10's is because it gives them a more SOTP feeling from 3:27's, than 3:73's. People are going by sotp instead of practicality.
Like in the 5.0L's...many go with 3:73's instead of 4:10's (even in 6,000rpm h/c/i cars)...because from the normal 2:73's...it is a bigger sotp feeling than 3:27's for them, for example.
3:73's for a daily driven car...
Your car will thank you
If you have nitrous, don't get 4:10's...traction and running into 5th gear become problems later.
Better to have less and want more, than have more and want less.