The main thing is to get it to breath.
Heads- Trickflow are some of the best. Eldelbrocks are good. Dart makes some too. If you're on a budget, you can find some GT40's off of an Explorer and get them ported, but 300 hp is gonna be harder to get to with these.
Valvetrain- Definitely get some 1.7 roller rockers, chrome moly pushrods made to proper length depending on cam, valvesprings to match. Crane, Comp, custom cam shops can help you here.
Cam- The best option here is to get a custom cam. There are lots of grinders (I'm sure others will chime in), but you can also call Crane or Comp and tell them you're combo and they'll get you a good one.
Intake- again, Trickflow, Edelbrock, ported Cobra/Explorer
Exhaust- HEADERS! The stock manifolds are insanily restrictive. Longtubes for torque and sound, shorties for hp and ground clearance. Off road H or X pipe and whatever mufflers you like the sound of.
That's the basic equation. Basically, do some research, talk to people, and go with what you like.