Honestly, it depends on the tune. There's quite a big difference in making 450 rwhp on stock heads/cams with 12+ psi and making 450 rwhp on Trickflow stuff at only 8 psi. Typically, the killer of these engines is DETONATION, not excessive power. Come to think of it, I can't think of ever hearing of just a rod going through the side of the block. It's ALWAYS "yea, I had some detonation and popped a ring/piston/rod". That's what happened when my motor let go last year. To only make 450 with the Trickflow, it will have to be very de-tuned (read: very rich and not much timing), which is inherently going to be safer. That doesn't mean that you can't create a new window in the side of your block, but I feel it's much less likely. Granted it was with a turbo, but tank_567 was making north of 500 rwhp for a good while (and racing regularly with it) before his motor let go. And it was the oil pump of all things that failed on his car.
Out of curiosity, how much power does your car make now and what's the fastest car you've owned?