what do you have already? what is your end game?
if you have a bone stock 5.0 and bolt on a vortech package, and operate it within the manufactures parameters...you'll be fine. IE, 5-7 psi, a FMU can handle that, the package is made to do that. Start straying away from what it is designed to do...swap pulleys/upgrading injectors, (exceed the as delivered design limitations)..then you have to let the computer know what it is working with,or you'll have troubles ranging from poor drivability, to leaning out on the top end..... ie tune time.
lot of guys like to ditch the FMU, go right with the bigger injectors, fuel pump, tune...if that is your intention, then save the bucks, cause you'll need the electronic manipulation....if you got the nice Vortech box in the garage and can't wait to put it on, go for it...just don't get out of line with it.
what I've done...put the KB on, 8psi, with the FMU. Beat on it pretty good, no problems. (well, did pop a HG, but that was self induced, swapped a pulley w/ a friend, no other changes) Put a bigger fuel pump in, after the original quit one day. Had the intentions of going with heads cam etc. Picked up a tweecer and been messing with it, learnign to use it. In the meantime, got the heads, cam, lower intake, injectors, MAF..etc...just need some spare time between kids, dogs, work, school, deploying to put it all together...soon. This didn;t happen over night. Moral of the story, have a plan.....
again, good luck!