Considering lots of Nitrous, what do you suggest?

One myth to put aside is Nitrous does not kill motors. Hp shortens the life of a motor. Whether it be turbo, nitrous, or wild compression and a wicked cam. HP puts added stress on parts regardless of the method you use to make it. An ill tune will kill any motor, including an N/A application. Blaming the death of the motor on the bottle is like blaming a murder on a gun.Nitrous makes HP, if your parts can't handle it, don't play with it. There is a limit for each part in your motor. If it is stock, you can run more nitrous until you reach its limits. If you have heads, cam, stroker, you are at the block limits right there. Add 150 hp of nitrous, split the block and blame it on the nitrous. Run 50-100 shot, premium fuel, and follow the directions EXACTLY and you'll be fine. I would be more afraid to run 100 shot on a stroker than a stock motor.
 
Nitrous is good but only if your parts could handle it. Parts that could not take the presure and heat will fail. I would say get forged pistons or just new piston rings and some good spark plugs change the radator fluid and something that will cool the engine fast and stay cold because when Nitrous is added into the engine it heats up fast. ohh yea and give it short bursts dont go crazy with it.