The advice to figure out a combo that you will keep for a while and going with it is the best out there. There is usually a lot to be gained from tuning, etc.
I was really pleased when my 82 cracked the 12's, with it 18 year old shortblock and iron Gt40 heads. But I actually gained the last second of et with tires, torque converter and rear suspension stuff.
I have tried the approach of buying parts and then having to upgrade something else to get them to work, and it costs a lot more in the long run.
I have had two complete carb and intake setups, two complete exhausts, etc, and all the expenses of changing, etc. It's on its 3rd set of heads, and each of the last two sets took about $5-700 for parts and machine work to install, and I still use bolt down stock rockers, etc.
I would be $1500 ahead if I had not played around, but, maybe thats just the price of this fun...